Manipulation Of Drug Release Behaviors Of Chitosan-based Orthopedic Nano-composites By Paa-coated Cdha Nanoparticles

摘要

It is known that the release behavior of polymeric delivery system is strongly influenced by polymer crystallinity, plasticization, glass transition temperature and swelling extent which are further affected by the existence of nano-fillers. However, the roles of nano-fillers in current researches were inconsistent [1 - 3], which was primarily due to the various interfacial interaction strength between fillers and polymeric matrices [4]. In order to clarify the role of the filler-polymer interaction on the drug release behaviors of Chitosan/Calcium deficient hydroxyapatite (CS/CDHA) nano-composite, implantable PAA (poly acrylic acid) was employed instead of highly toxic silane as a physical coupling agent to enhance chitosan-CDHA interfacial interaction via electrostatic force. Although PAA has been reported to improve the mechanical properties of chitosan/HAp composite [5], studies on the effects of PAA-coated CDHA nano-crystals on the drug release behaviors of chitosan/CDHA nano-composites were not available.