DEVELOPMENT OF INDUSTRIAL CRYSTALLIZATION OF DOXORUBICIN HYDROCHLORIDE THAT HAS EXCELLENT CHARACTERISTICS AS AN ACTIVE PHARMACEUTICAL INGREDIENT

摘要

We will report our excellent development in crystallizing doxorubicin hydrochloride (DXR HCl) that was performed by carrying out the crystallization at 40°C or higher degrees. This advanced method is efficient for producing DXR HCl crystals with low residual solvents, good water solubility, high stability against heat, and low hygroscopicity. These improvements in physico-chemical properties were supposed to result from a good crystal growth, that is larger crystals were formed than the previous method.