Reproductive Outcome After Laparoscopic Myomectomy and Hyaluronic Acid Gel Application

摘要

To assess the reproductive outcome after laparoscopic myomectomy and post-surgical adhesions prevention with auto-crosslinked HA gel. Thirty-six infertile women underwent laparoscopic myomectomy. Eighteen were treated with HA gel for (group A), 18 were untreated (group B). All patients underwent post-surgical adhesions evaluation and a reproductive outcome follow-up for 12 months. Patients who did not conceive, after 6 month, underwent ultrasonographic monitoring of ovulation from 7th to 12th follow-up month. In this period 4 out of 10 patients of group A and 5 out of 14 of group B underwent controlled ovarian hyperstimulation. At 1 year follow-up, pregnancies occurred in 77.8% of patients in group A and in 38.8% of cases in group B. Auto-crosslinked HA gel is useful to prevent postsurgical adhesions formation in infertile patients after laparoscopic myomectomy and it increase the pregnancy rate more than laparoscopic myomectomy alone.