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Production Logistics and Prospects of ~142Pr and ~143Pr for Radionuclide Therapy (RNT) Applications

机译:〜142pr〜143pr的生产物流和前景〜143pr用于放射性核素治疗(RNT)应用

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1. Introduction: The introduction of a variety of radiopharmaceuticals for the internal therapy of malignant or inflammatory lesions during the past decade has been a notable feature. The use of certain bone seeking radiopharmaceuticals is becoming increasingly popular because their use tends to relieve the metastatic bone pain without the undesirable side effects associated with narcotics. Several compounds of radionuclides like ~89Sr, ~188Re, ~153Sm, ~166Ho, ~90Y, ~32P etc are currently used in palliation therapy [1]. The choice of a radionuclide for therapeutic applications is governed by various factors such as the characteristics of radiations emitted (type and energy of radiation), half-life, specific activity, ease of production, natural abundance of target nuclide, radionuclide purity and the feasibility of producing the radionuclide in a suitable form for application. Pure beta-emitting radionuclides are often preferred for use in clinical radionuclide therapy (RNT), while the merits of accompanying gamma emissions in low abundance to facilitate imaging and dosimetry are notable as well described in literature [2].
机译:1.简介:在过去十年中引入用于内部治疗恶性或炎症病变的内部治疗的放射性药物一直是一个值得注意的特征。使用某些骨头寻找放射性药物的使用变得越来越受欢迎,因为它们的使用往往能够缓解转移性骨疼痛而没有与麻醉剂相关的不良副作用。几种放射性核素类化合物,如〜89sr,〜188重,〜153sm,〜166ho,〜90y,〜32p等目前用于Palliation疗法[1]。用于治疗应用的放射性核素的选择受各种因素的管辖,例如排放的辐射特性(辐射类型和能量),半衰期,特异性活动,生产易于生产,天然丰富的靶核素,放射性核素纯度和可行性以合适的施用制备放射性核素。纯β发射的放射性核素通常优选用于临床放射性核素治疗(RNT),而伴随γ排放的低丰度促进成像和剂量测定的优点是值得注意的[2]。

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