Evaluation of prognostic value of CA125 serum levels in ICSI outcome

摘要

Introduction: Endometrial receptivity is an important factor in embryo transfer. CA125 is a recently considered glycoprotein that is produced by normal endometrium There is a controversy about CA125 as an indicator of endometrial receptivity and a predictor of pregnancy. Settings: Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, TUMS,, Materials and Methods: In this cross-sectional study, 120 intracytoplasmic sperm injection (ICSI) cases during March 2001-2002 were included In addition to the assessment of association of variables with ICSI results, the prognostic value of CA125 serum concentration on the day of HCG administration and oocyte retrieval day was evaluated using an enzyme immunometric assay Patients were divided in to two groups, pregnant and nonpregnant, based on transvaginal ultrasonography evaluation and were compared in terms of demographic and laboratory characteristics The predictors of pregnancy were determined by using logistic regression model Results: Pregnancy was obtained in 27 (22,5%) cycles. In the univariate analysis, the number of the transferred embryos (p= 0.007) and the serum levels of estradiol (P=0 006) were significantly associated with pregnancy outcome The mean levels of CA125 > 16 IU/ml on the day of oocyte retrieval showed a marginally significant difference between pregnant and nonpregnant women (P= 0 05), but there was no significant association between serum levels of CA125 > 10 IU/ml on the day of HCG administration and pregnancy outcome (P=0.12). In the logistic regression model, the number of transferred embryos > 3 (OR: 1,8, 95% CI: 1.2-2.8, P=0 01) and serum estradiol levels > 1200 pg/ml (OR: 15, 95% CI: 3-76, P= 0.02.3) were the only important predictors of pregnancy in ICSI Conclusion: According to the multivariate analysis, serum CA125 levels cannot be used as predictor of pregnancy before embryo transfer in assisted reproductive technologies (ART) cycles.