Use of Oxycodone CR in Post-operative Pain Control After Gynecologic Surgery

摘要

The aim of our study was to evaluate the analgesic efficacy and the acceptability of Oxycodone CR in post-operative moderate to severe pain after gynecologic surgery.72 women scheduled for gynecologic surgery, were randomly divided in two groups receiving post-operative intravenous analgesia (PCA group) or oral analgesia (Oxycodone CR group). We monitored: ECG, NIBP, SO_2, HR, postoperative, side effects, patients'satisfaction, sleep interference, drowsiness, use and frequency of the rescue dose.Postoperative VAS pain score was significantly lower in CR oxycodone group than the PCA group. There was a lower frequency of sleep disturbance, postoperative nausea, vomiting and drowsiness in the group Oxycodone CR than the PCA group (p<0,05). Oxycodone CR group appeared more satisfied than the PCA group. Our data show that the use of post-operative CR Oxycodone in gynecologic surgery determinates a good analgesia with a lower sedation, post-operative nausea and vomiting incidence and higher satisfaction of patients.