~(13)C CPMAS AND ~1H NMR STUDY OF THE INCLUSION COMPLEXES OF β-CYCLODEXTRIN WITH CARVACROL, THYMOL AND EUGENOL PREPARED BY SUPERCRITICAL CARBON DIOXIDE

摘要

β-cyclodextrin inclusion complexes with carvacrol, thymol and eugenol (components of essential oils of vegetable origin) were prepared by the supercritical carbon dioxide technique and their structural characterisation was made by means of 1H NMR in aqueous solution and ~(13)C CPMAS NMR in the solid state. Evidence of the formation of the inclusion complexes for all the examined systems was obtained by ~1H NMR in solution, while 2D-ROESY NMR experiments were used to investigate the geometry of inclusion. In addition, the dynamics of these inclusion complexes in the kilohertz timescale was investigated by analysis of the proton and carbon spin-lattice relaxation times in the rotating frame.