Diet as a Determinant of Drug Response

摘要

Therapeutic drags and food are often taken together. Linking drag administration to a regular event like a meal can improve compliance with a treatment regimen, especially in elderly people (1). However, concomitant drug and food intake creates the opportunity for an interaction that may increase or decrease drug effectiveness or toxicity. The response to a drug is largely dependent on its concentration at specific cells in the body. An increased drag concentration generally causes an enhanced magnitude and duration of effect, whereas a decreased drug concentration produces the opposite result. The concentration of an orally administered drug at the cellular site of action is determined by the net result of the rate and extent of absorption of the drag from the gastrointestinal tract into the systemic blood circulation (that is, its oral bioavail-ability), the distribution of the drug from the circulation to the target cells, and the removal of the drug from the site of action by its elimination from the body.