Impact of circulating superoxide dismutase levels in adipocytokines and oxidative stress. Unexpected behaviour of nitrotyrosine and oxidized ldl.

摘要

Superoxide dismutases (SOD) are an important antioxidant defense both outside (tissue cells) and inside the bloodstream. Aims: To determine if low levels of SOD are associated with changes in adipocytokines and biomarkers. Methods: N= 204 with moderate-high CV risk. SOD, hs-TNF-alpha, Resistin, IL-6, TBARS, TAC, oxLDL and NT were evaluated. Results The low-SOD group presented higher TBARS and lower TAC. Adipocytokine TNF-alpha, unlike IL-6 and resistin, showed higher levels in patients with diminished SOD. Surprisingly lower values of NT and oxLDL were obtained in the low-SOD group. Both statin treatment and diabetic status were ruled out as cause of these unexpected results. Conclusions: Diminished SOD levels are accompanied by elevated TNF- alpha. Low-SOD is related to oxidative stress measured by TAC and TBARS.