Involvement of Oxidative Stress in Experimental Atherosclerosis: Experimental Study with Agaricus Sylvaticus and Antioxidant Vitamins Supplementation

摘要

To test the potential preventive effect of A. sylvaticus on atherosclerosis, 27 New Zealand rabbits underwent atherosclerosis induction, 11 of them received cholesterol enriched chow for 10 weeks (Group A), while 6 (Group B) simultaneously received vitamin C and E, and 10 Agaricus sylvaticus mushroom water solution (Group C). Control group received normal chow only (Group D; N=10). Groups A, B and C presented cholesterol levels significantly higher and reduced antioxidant capacity, when compared to Group D. TBARS values for group C was statistically reduced when compared to groups A and B and equals to those of group D Moreover, animals from group A developed extensive atherosclerotic areas over the aorta, and that was partially prevented by the use of vitamins C and E or mushroom. Concluding, the use of antioxidant vitamins or A. sylvaticus can prevent the development of atherosclerosis.