Inhibition of islet amyloid polypeptide (IAPP) amyloid formation and cytotoxicity via structure-based,selective N-methylation of amide bonds of amyloid core sequences

摘要

Pancreatic amyloid is present in more than 95% of type II diabets patients and is formed by the aggregation of the 37-residue iselt amyloid polypeptide (IAPP).IAPP amyloid aggregates are cytotoxic and have been linked to the progressive of beta-cell function and the pathological sequelae of type II diabetes [1].