Chiral peptide nucleic acids:design,synthesis,optical purity and hybridization properties

摘要

Peptide nucleic acids (PNAs) are DNA mimic pseudopeptide,first described by Nielsen and co-workers in 1991[1],which have attracted a great interest because of their highly specific and very stable DNA binding [2].Due to their outstanding behavior,PNAs are currently used in a plethora of biological applications which require specific DNA recognition,such as detection of point mutations,genetic probing by in situ hybridisation,PCR clamping,inhibition of transcription and of translation and many others.