Conformational properties of c_3Val,a C~alpha-tetrasbustituted,C~beta-branched,C_i~alpha reversible C_i~alpha cyclized,chiral alpha-amino acid

摘要

The relevance of stable secondary structure elements in peptides and proteins has inspired considerable effort toward the design of rigidified artificial molecules.In particular,significant progess has been made in engineering and synthesizing turn and helix inducers and mimetics.Indeed,turn and helical motifs are fundamental constituents of many biologically active peptides and are often critical for their biological activity.