Main-chain length effect on conformation-activity relationship of membrane active lipopeptaibol antibiotics

摘要

Trichoderma fungi biosynthesize antimicrobial peptides (peptaibols) that are known as efficient membrane modifiers [1].Peptaibols are linear peptides characterized by the C~alpha-tetrasubstituted alpha-amino acid Aib (alpha-aminoisobutyric acid) and a C-terminal 1,2-aminoalcohol.