AMINO ACID SEQUENCES OF S GLYCOPROTEIN GENE OF TGEVs ISOLATED IN KOREA

摘要

Transmissible gastroenteritis virus (TGEV) causes a highly contagious enteric disease in swine, resulting in severe economical losses to the affected farms. TGEV belongs to the family coronaviridae. TGEV has three structural viral proteins, spike (S)protein, nucleoprotein (N), and membrane (M) protein. The S protein forms the peplomers on the virion envelope, induces neutralizing antibodies, contains receptor binding regions, and contains major four antigenic sites (A, B, C, D). The purpose of the present study was to characterize TGEVs (KT2, KT3, KT4, KT5 and KT6) isolated in Korea. For the above purpose, the N-terminal half region of S glycoprotein gene including sites A, B, C and D of the Korea TGEV isolates was sequenced and compared with previous Korean TGEV isolates, published foreign TGEVs and PRCV sequences.