Endometriosis. Is IVF the Answer for Infertility? Stage-related Success Rates in 1417 Consecutive IVF-ET Cycles

摘要

Endometriosis is a common cause of infertility and a frequent indication for IVF-ET. We describe the outcome of 1417 consecutive cycles in 872 patients with endometriosis undergoing IVF-ET at The New York Presbyterian Hospital -^sWeill Medical College of Cornell University; 1196 (84.4%) of the 1417 initiated cycles underwent retrieval. Of these, 1105 (92.3%) underwent an embryo transfer. An overall clinical pregnancy rate/transfer of 44.7% (495/1105) and an overall ongoing pregnancy rate/transfer of 37.1% were achieved. Stage of disease had no significant effect on outcome. To remove the bias of individual patients with multiple failed cycles, we analyzed the first cycle of each patient with endometriosis. Once again, the stage of disease had no significant effect on outcome. The impact of disease stage on ovarian stimulation protocols was evaluated in leuprolide down-regulated cycles. Mild disease was associated with better ovarian response, although no differences were observed in oocyte recovery and pregnancy rates.