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Synthesis of oligodeoxynucleotide-peptide conjugates using hydrazone chemical ligation

机译：用腙化学结扎合成寡脱氧寡核苷酸肽缀合物

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摘要

Oligonucleotides constitute a class of potential therapeutic agents.Improvement of certain properties,such as cell-specific delivery,cellular uptake efficiency,intracellular distribution,and target specificity can be accomplished by covalent association to peptides.

机译：寡核苷酸构成一类潜在的治疗剂。通过与肽的共价联合可以实现某些性能，例如细胞特异性递送，细胞吸收效率，细胞内分布和靶特异性。

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《the International Peptide Symposium》|2001年||共2页
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Oleg Melnyk; Nathalie Ollivier; Christophe Olivier; Catherine Gouyette; Tam Huynh-Dinh; Helene Gras-Masse;
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中图分类肽类;
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专利

1. Synthesis of oligonucleotide-peptide conjugates using hydrazone chemical ligation [J] . Nathalie Ollivier, Christophe Olivier, Catherine Gouyette, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2002,第6期

机译：化学连接法合成寡核苷酸-肽结合物
2. Combined thioether/hydrazone chemoselective ligation reactions for the synthesis of glycocluster-antigen peptide conjugates [J] . Cyrille Grandjean, Valerie Santraine, Jean-Sebastien Fruchart, Bioconjugate Chemistry . 2002,第4期

机译：硫醚/ hydr联合化学选择性连接反应合成糖簇-抗原肽偶联物
3. Combined thioether/hydrazone chemoselective ligation reactions for the synthesis of glycocluster-antigen peptide conjugates [J] . Cyrille Grandjean, Valerie Santraine, Jean-Sebastien Fruchart, Bioconjugate Chemistry . 2002,第4期

机译：硫醚/ hydr联合化学选择性连接反应合成糖簇-抗原肽偶联物
4. Synthesis of oligodeoxynucleotide-peptide conjugates using hydrazone chemical ligation [C] . Oleg Melnyk, Nathalie Ollivier, Christophe Olivier, the International Peptide Symposium . 2001

机译：用腙化学结扎合成寡脱氧寡核苷酸肽缀合物
5. Synthesis of selenium-alkylated selenocysteine derivatives and their use in native chemical ligation, expressed protein ligation and the synthesis of dehydropeptides. [D] . Gieselman, Matthew Douglas. 2003

机译：硒烷基化硒代半胱氨酸衍生物的合成及其在天然化学连接，表达蛋白连接和脱氢肽合成中的应用。
6. Synthesis physiochemical characterization and in vitro antitumor activity of the amide and pH cleavable hydrazone conjugates of γ-tocotrienol isomer of vitamin E with methoxy-poly(ethylene) glycol [O] . Ahmed Abu-Fayyad, Sami Nazzal -1

机译：维生素E与甲氧基聚乙二醇的γ-生育三烯酚异构体的酰胺和pH可裂解的共轭物的合成理化特性和体外抗肿瘤活性
7. Synthesis, physiochemical characterization, and in vitro antitumor activity of the amide and pH cleavable hydrazone conjugates of γ-tocotrienol isomer of vitamin E with methoxy-poly(ethylene) glycol [O] . Ahmed Abu-Fayyad, Sami Nazzal 2017

机译：用甲氧基 - 聚（乙烯）乙二醇的γ-Tocotrienol异构体的酰胺和pH可切割腙缀合物的合成，生理化学表征和体外抗肿瘤活性

Synthesis of oligodeoxynucleotide-peptide conjugates using hydrazone chemical ligation

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