Ethyl nitroacetate as a useful synthon for the synthesis of orthogonally protected,poly-functional C~(alpha,alpha)-disubstituted amino acids

摘要

The discovery of C~(alpha,alpha)-disubstituted amino acids (alphaalpha AAs) and their propensity to induce secondary structure even into short peptides has resulted in an increased interest in novel methods for their synthesis.Herein ethyl nitroacetate,a useful synthetic intermediate for a variety of biologically significant compounds,has been employed for the preparation of sterically hindered and polyfunctional alphalphaAAs which are suitable for incorporation into peptides.