Lipoamino acid and liposaccharide conjugated peptides:enhancement of bioavailability

摘要

The most convenient way to administer drugs is by oral administration.However,intestinal absorption of peptides/proteins is relatively poor,mainly due to extensive enzymatic degradation in the gastrointestinal tract.The aim of the present study was to improve the intestinal absorption and stability of a model peptide IT-100 by chemically conjugating it with a lipid and sugar based carrier system.