Overexpression of Conserved Kinase UNC-51 Inhibits the Transferrin's Endocytosis into the Mammalian Cells

摘要

UNC-51 overexpression can inhibit the transferrin endocytosis in the transfected COS-7 cells. We think that this inhibition of transferrin endocytosis should be caused by UNC-51-dependent microtubule-disruption (being submitted to Science Signaling).Endocytosis is crucial to many cellular functions, for example, axon formation and synaptic transmission, antigen presentation, cancer, pathogen entry [1-3]. But, the precise molecular mechanisms for endocytosis are unclear. Conserved UNC-51 is essentialfor the axon formation, thus, we expressed Myc-tagged UNC-51 in COS-7 cells to analyze how or whether UNC-51 affects the transferrin's endocytosis into the cells.