A physiologic-based circuit model of excitation and inhibition in the postsynaptic neuron

摘要

A metal-oxide-semiconductor field-effect transistor (MOSFET) represents the variable conductance of transmitter-gated ion channels in the input (or postsynaptic) region of the neuron. The MOSFET is incorporated into a circuit model of the postsynaptic membrane. Simulation of the circuit yields an output representing the membrane potential of the input region. Simulation is performed for the excitatory, inhibitory and combined excitatory-inhibitory states.