Highly distorted urea based channel lattice complexes as analternative to solid dispersions for improving content uniformity anddissolution rate

摘要

Normally nonadductible endocytic drugs (NNAED) such as vitamin Eand famotidine were successfully included in urea in the presence of arapidly adductible endocyte (RAE). Formation of urea based conclusioncompounds of vitamin E and famotidine was confirmed by IR spectroscopy,DTA, polycrystalline X-ray diffraction and calorimetric analysis.Weakening of the hexagonal lattice of host urea owing to distortioncaused by the presence of highly substituted NNAED was exploited for theenhancement of dissolution rate of famotidine and vitamin E. Thesimultaneous accomplishment of improved content uniformity and anenhanced dissolution rate, due to ease in dispersion of the drug at amolecular level offer this technique a vast potential as an alternativeto conventional solid dispersions