Anti-Arthritic Effects of Chondroitin Sulfate and Type II Collagen in Collagen-Induced Arthritis Mice

摘要

The anti-arthritic effects of the Chondroitin Sulfate and Type II Collagen in Kunming mice with type II collagen-induced arthritis (CIA) were investigated in the present study. 50 mice were randomly divided into 5 groups: control group, model group, chondroitin sulfate (CS) group, type II collagen (CII) group and mixed (MX) group. CIA mice model was set up by injecting with 100 μg of CII emulsified in ICFA at the right rear foot after oral administration of Chondroitin Sulfate and Type II Collagen for 3 weeks. Arthritis index was analyzed. We detected the serum levels of interleukin-1β (3 (IL-β), tumor necrosis factor (TNF-α) and gelatinizes MMP-9. Splenic lymphocyte proliferation, natural killer (NK) cell activity and peritoneal macrophage phagocytic activity were determined. Results indicated that pre-treatment of chondroitin sulfate and type II collagen could effectively attenuate the severity of rheumatoid arthritis.