A multi-task learning method for analyzing microbiota as cancer immunotherapy signal

摘要

Researches have found that tumor immunotherapy can only work for some patients, and the intestinal microbiota is one of the important factors affecting the responses of patients with cancer to immune checkpoint blockade therapy. It is highly desirable to develop computational methods that can predict whether a patient with cancer will have positive effects on cancer immunotherapy by analyzing intestinal microorganisms of the patient. In this study, a multi-task model is introduced to predict the efficacy of cancer immunotherapy on a patient who suffered from non-small cell lung cancer or renal cell carcinoma. The results demonstrate the multi-task model outperforms several single-task methods. Therefore, we believe the multi-task idea can be used to predict the efficacy of cancer immunotherapy based on the gut microbe, which would be important to cancer patients.