PROLIFERATION AND FIBER FORMATION OF HUMAN DERMAL FIBROBLASTS ON PATTERNED DIFFERENTIALLY ADHERENT SUBSTRATES

摘要

Fibroblast cells are crucial in the human body for maintenance of the extracellular matrix, including synthesizing macromolecules like collagen, and they play a critical role in wound healing of soft tissues such as skin [1]. Directing fibroblast growth is an important step in tissue engineering where the focus has gone from a top-down approach of homogeneously introducing cells into a pre-formed scaffold to a bottom-up approach in which the tissue construct is built on a cell-by-cell basis with ability to manipulate specific cell environments through location, proximity, and geometry.