PREDICTION OF SHEAR INDUCED PLATELET ACTIVATION IN PROSTHETIC HEART VALVES BY INTEGRATING FLUID-STRUCTURE INTERACTION APPROACH AND LAGRANGIAN-BASED BLOOD DAMAGE MODEL

摘要

Altered haemodynamics are implicated in the blood cells damage that leads to thromboembolic complications in presence of prosthetic cardiovascular devices, with platelet activation being the underlying mechanism for cardioemboli formation in blood flow past mechanical heart valves (MHVs). Platelet activation can be initiated and maintained by flow patterns arising from blood flowing through the MHV, and can lead to an enhancement in the aggregation of platelets, increasing the risk for thromboemboli formation. Heliums and colleagues compiled numerous experimental results to depict a locus of incipient shear related platelet activation on a shear stress -exposure time plane, commonly used as a standard for platelet activation threshold [1].