Peroral peptide drug delivery using superporous hydrogel (SPH) and SPh composite polymers: drug release and enzyme inhibition studies

摘要

In the last two decades numerous attempts have been made by many scientists to overcome the prolbem of peroral absorption of peptide and protein drugs. Different approaches have been proposed, such as using mucoadhesive polymers, applying penetration enhancers to interact iwth the gut membrane, using enzyme inhibitors and/or substances to open the tight junctions in order to enhance the poor peptide absorption and low bioavailability. In this study, a novel drug delivery system for intestinal absorption of peptide and protein drugs is designed with the use of superporous hydrogel (SPH) and SPH composites polymers. One of the outstanding characteristics of this new delivery system is its mechanism of action. These polymers are able to swell very rapidly by absorption of gut fluids, so they can mechancially attach to the intestinal wall and keep the dosage form at the site of action for a specific period of time in which the drug will be released and absorbed. In this report, the capacity of these polymers for enzyme inactivation is also described.