Antihyperuricemic Activity of Ginger Flower (Etlingera elatior Jack.) Extract in Beef Broth-Induced Hyperuricemic Rats (Rattus norvegicus)

摘要

Hyperuricemia can be induced by the high level of uric acid in the blood. Ginger flower (E. elatior Jack.) contains flavonoid, phenol and glycoside. Polyphenol and flavonoid have been reported having Xantine Oxidase Inhibitor (XOI) activity that can help for decreasing uric acid levels. Hence, the ginger flower can be used as a candidate of traditional hyperuricemia medicine. The objective of this study was to analyze the ability of ginger flower extract to decrease uric acid level in the hyperuricemic rat. Methods of this study were sample collection and preparation of ginger flower extract by infundation method, induction of hyperuricemic rat using per oral administration of beef broth at dose of 700 mg/kg body weight, treatment of hyperuricemic rat using ginger extract at dose of 200 mg/kg body weight and allopurinol as uric acid drug at dose of 180 mg/kg body weight and measurement of uric acid concentration. Results showed that ginger flower extract decreased uric acid concentration until 31.78% on discontinuous hyperuricemic induction sub-group and 17.90% on continuous hyperuricemic induction sub-group. Allopurinol decreased uric acid concentration until 45.65% on discontinuous hyperuricemic induction sub-group and 23.53% on continuous hyperuricemic induction sub-group. Hence, the ginger flower had the ability to decrease uric acid concentration in hyperuricemic rat into the normal level.