A modified functionalized magnetic Field for nanoparticle guidance in magnetic drug targeting

摘要

Magnetic drug targeting is a method to steer and concentrate magnetic nanoparticles (MNPs) in a desired location in body. In our recent work, we have investigated the effective parameters of a field function to improve the process effectiveness. In this paper, based on the assessment and experimental process, in fact, we focus on proposing a modified version of Field Function (MVFF) to improve the guidance system consistent with experimental facts. We will use an electromagnetic actuator (EMA) system which consists of two coil-core system. The cores are added in the center of each coil to concentrate the flux in the region of interest. Effective guidance of MNPs is demonstrated via simulations and experiments using 750-nm-diameter MNPs (SiMAG-Silanol 1101 of Chemicell Company) in a 1 mm Y-shaped channel. To evaluate the effectiveness of the MVFF, the concentration of correct outlet and incorrect outlet has been measured using the experimental set up it has been proven that the proposed MVFF demonstrates a move efficient results.