Clinical efficacy of Xi Sanzang Decoction assisted knee arthroscopic treatment for Knee Osteoarthritis due to deficiency of liver and kidney and its influence on serum cytokines

摘要

Objective: To explore the clinical efficacy of Xi Sanzang Decoction assisted knee arthroscopic treatment for knee osteoarthritis (KOA). Methods: A total of 82 patients with KOA due to deficiency of liver and kidney were selected and randomized into treatment group and control group using random number table. Treatment group was treated with knee arthroscopic rinsing followed by Xi Sanzang Decoction which was decocted by water and administered orally, bid, 7 days as a cycle. Control group was treated with Glucosamine Hydrochloride Capsules, 2 capsules per time, tid, 7 days as a cycle. The improvement of Lysholm score and visual analogue scale (VAS) score before and after treatment, the clinical efficacy and the levels of serum cytokines were observed in both groups after 2 cycles of treatment. Results: (1) Intra-group comparison: Lysholm score and VAS score were significantly improved after treatment than treatment before in both groups, and there were significant differences (P<0.01). (2) Inter-group comparison after treatment: Treatment group was prominently better in Lysholm score and VAS score and evidently higher in clinical efficacy than those in control group, and there were significant differences (P<0.05). (3) Treatment group was notably lower than control group in the serum levels of interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) after treatment, and there were significant differences (P<0.05). Conclusion: Xi Sanzang Decoction assisted knee arthroscopic treatment is excellent in clinical efficacy and safe and reliable in clinical application for KOA.