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Impact of functionalized Gelatin-Methacrylate hydrogels on hematopoietic stem cell biology

机译:功能化明胶-甲基丙烯酸甲酯水凝胶对造血干细胞生物学的影响

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We have demonstrated the ability to functionalize a GelMA hydrogel with a cytokine regulator of HSC fate, and maintain the activity of the factor in culture. Further, via selective alteration of matrix diffusivity we have established a biomaterial platform to explore the influence of niche cell and cytokine mediated paracrine signaling on HSC fate decisions. Ongoing experiments are examining longer culture periods to alter the balance between lineage specification and quiescence.
机译:我们已经证明有能力用HSC命运的细胞因子调节剂功能化GelMA水凝胶,并在培养物中维持该因子的活性。此外,通过选择性改变基质的扩散性,我们建立了一个生物材料平台,以探索利基细胞和细胞因子介导的旁分泌信号对HSC命运决定的影响。正在进行的实验正在研究更长的培养期,以改变谱系规格和静止之间的平衡。

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