Integration of Cysteine-rich angiogenic inducer 61 (CYR61) into collagen biomaterial promotes the therapeutic potential of circulating angiogenic cells

摘要

We demonstrate that the expression of integrins is significantly altered when culturing CACs on a collagen matrix. The discovery of which specific integrins are expressed under these conditions helped identify CYR61 as a potential protein to improve the matrix. CYR61 added to the matrix enhanced CAC migration and adhesion, and promoted vascularization and perfusion of ischemic tissue. These findings demonstrate a novel mechanism which may be used to better restore perfusion and function of ischemic tissue in cell-matrix therapy.