Clinical Trial and Preparation of Amniotic Membrane as Dura Mater Artificial

摘要

Duraplasty is a common procedure while human dura mater cannot be sutured during surgery and required a dural graft. Some material has been studied as dura mater substitute. One of those materials is amniotic membrane that used frequently in the surgical procedure. A clinical experimental study was performed to analyze the healing of dural in 8 patients at Dr. Soetomo General Hospital Surabaya, Indonesia. The amniotic membrane allograft, had been processed and folded in 16 layers. The membrane was then sutured to cover the dural defect. Ten weeks later, the patient underwent cranioplasty and CSF leakage evaluated by checking the edge of dural. The fibrocyte infiltration was examined histologically. Based on the analysis, the amniotic membrane showed great potential as dura mater artificial.