首页> 外文会议>Annual meeting of the Society for Biomaterials >Extracellular matrix proteins mediate osteogenic differentiation of human mesenchymal stem cells on phosphate functionalized gels through integrin mediated focal adhesion kinase signaling
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Extracellular matrix proteins mediate osteogenic differentiation of human mesenchymal stem cells on phosphate functionalized gels through integrin mediated focal adhesion kinase signaling

机译:细胞外基质蛋白通过整合素介导的粘着斑激酶信号传导介导人间充质干细胞在磷酸盐功能化凝胶上的成骨分化

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Differentiation of human mesenchymal stem cells (hMSCs) has been shown to be dependent on various biochemical and biophysical cues. Benoit et al (1) demonstrated that small functional groups when incorporated into poly(ethylene glycol) (PEG) gels can induce differentiation of hMSCs. The phosphate (PO_4) functionality has been shown to induce osteogenic differentiation in hMSCs in the absence of osteogenic supplements (OS).
机译:人类间充质干细胞(hMSCs)的分化已显示取决于各种生化和生物物理提示。 Benoit等人(1)证明,小的官能团在掺入聚乙二醇(PEG)凝胶时可以诱导hMSC的分化。磷酸盐(PO_4)的功能已显示出在没有成骨补充剂(OS)的情况下在hMSC中诱导成骨分化。

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