Pegylated quarternized chitosan as novel gene delivery vector

机译：聚乙二醇化季铵化壳聚糖作为新型基因传递载体

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In this study, we compare physicochemicalproperties and transfection efficiencies of low MWchitosan (LMW-C), trimethyl chitosan (TMC) andpegylated trimethyl chitosan (PEG-TMC).Quarternization and pegylation only slightly altersphysicochemical properties of polyplexes. Incontrast transfection efficiency is strongly increasedwith both TMC and PEG-TMC compared to LMW-C.

机译：在这项研究中，我们比较了理化分子量的特性和转染效率壳聚糖（LMW-C），三甲基壳聚糖（TMC）和聚乙二醇化三甲基壳聚糖（PEG-TMC）。四分之一化和聚乙二醇化仅稍有改变复合物的理化性质。在对比转染效率大大提高与LMW-C相比使用TMC和PEG-TMC。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Oliver Germershaus; Shirui Mao; Anchalee Jintapattanakit; Thomas Kissel;
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中图分类药学;
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Pegylated quarternized chitosan as novel gene delivery vector

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