Apoptosis Induced in Ovarian Cancer Cells by HPMA Copolymer-Bound DoxorubicinIs Mediated by Bcl-2 Family Proteins

机译：Bcl-2家族蛋白介导的HPMA共聚物结合的阿霉素诱导卵巢癌细胞凋亡。

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The mechanisms of cell death induced by N-(2-hydroxypropyl)methacrylamide (HPMA) copolymerboundand free doxorubicin was investigated. Inparticular, the involvement of the Bcl-2 family proteins indrug-induced apoptosis in human ovarian cancer cell lineA2780 was studied. It was demonstrated that HPMAcopolymer-bound doxorubicin alters the mitochondrialmembrane potential and decreases the expression of Bcl-2protein in A2780 cells.

机译：N-（2- 羟丙基）甲基丙烯酰胺（HPMA）共聚物并研究了游离阿霉素。在特别是Bcl-2家族蛋白的参与药物诱导人卵巢癌细胞凋亡研究了A2780。证明了HPMA 共聚物结合的阿霉素改变线粒体膜电位并降低Bcl-2的表达 A2780细胞中的蛋白质。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Alexander Malugin; Pavla Kopecková; Jindrich Kopecek;
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中图分类药学;
关键词
anticancer agents; apoptosis; cell culture; HPMA copolymers; doxorubicin;

机译：抗癌药;凋亡;细胞培养; HPMA共聚物;阿霉素;

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专利

1. Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance. [J] . Tijerina M, Fowers KD, Kopeckova P, Biomaterials . 2000,第21期

机译：将人卵巢癌细胞长期暴露于游离的或HPMA共聚物结合的中氯霉素e6不会诱导P-糖蛋白介导的多药耐药性。
2. HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function. [J] . Malugin A, Kopeckova P, Kopecek J Molecular pharmaceutics . 2006,第3期

机译：HPMA共聚物结合的阿霉素通过破坏线粒体功能来诱导卵巢癌细胞凋亡。
3. HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway. [J] . Malugin A, Kopeckova P, Kopecek J Molecular pharmaceutics . 2004,第3期

机译：HPMA共聚物结合的阿霉素通过不依赖Fas的途径诱导人卵巢癌细胞凋亡。
4. Role of caspases on cellular signal transduction pathways of apoptosis induced by free and hpma copolymer-bound doxorubicin [C] . T.Minko, P.Kopeckova, J.Kopecek International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：半胱天冬酶在游离和hpma共聚物结合的阿霉素诱导的细胞凋亡的细胞信号转导途径中的作用
5. Regulation of apoptosis by the Bcl-2 family of proteins in the LNCaP prostate cancer cell line progression model. [D] . Rothermund, Christy Ann. 2003

机译：LNCaP前列腺癌细胞系进展模型中Bcl-2蛋白家族对细胞凋亡的调节。
6. HPMA COPOLYMER-BOUND DOXORUBICIN INDUCES APOPTOSIS IN OVARIAN CARCINOMA CELLS BY THE DISRUPTION OF MITOCHONDRIAL FUNCTION [O] . Alexander Malugin, Pavla Kopeèková, Jindøich Kopeèek -1

机译：HPMA共聚物结合的阿霉素通过线粒体功能的破坏诱导卵巢癌细胞凋亡。
7. HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Ovarian Carcinoma Cells by the Disruption of Mitochondrial Function [O] . Alexander Malugin, Pavla Kopečková, Jindřich Kopeček 2006

机译：HPMA共聚的多柔比星通过断层术函数诱导卵巢癌细胞的细胞凋亡

Apoptosis Induced in Ovarian Cancer Cells by HPMA Copolymer-Bound DoxorubicinIs Mediated by Bcl-2 Family Proteins

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