PRODRUG TARGETING USING HYDROLASES : BIPHENYL HYDROLASE-LIKE (BPHL) HYDROLYZES VALACYCLOVIR, AN ESTER PRODRUG OF ACYCLOVIR

摘要

An enzyme responsible for L-valyl acyclovir hydrolysis was purified from Caco-2 cells. Besides to valacyclovir, VACVase hydrolazes glycyl-ACV and valyl-AZT. Biphenyl hydrolase-Like (BPHL), a serine hydrolase cloned originally from breast carcinoma was identified as a highly relevant enzyme to VACVase.