Effect of vehicles, penetration enhancers and pressure-sensitive adhesives on transdermal delivery of melatonin

摘要

The effects of vehicles, penetration enhancers, and pressure-sensitive adhesives on the in vitro permeation of melatonin through dorsal hairless mouse skin were investigated. PGL, IPM, PGML and PGMC showed high permeation fluxes and PGL, PGML and PGMC decreased lag time significantly. In both of the binary co-solvents of DGME-PGL and DGME-IPM, the highest fluxes were achieved at 20% of DGME, which were 10.5 +-1.5 and 9.1 +-2.4 μg/cm~2/h, respectively. Among fatty acids used, capric acid and oleic acid enhanced permeation significantly. In the matrix formulation, PGMC showed the highest flux compared to PGL or DGME-PGL (20 : 80 v/v); and the permeation flux was 3.03 +-1.37 μg/cm~2/hr. The permeation flux increased dose-dependently.