A NOVEL BIOMATERIAL BASED ON COLLAGEN/HYDROXYAPATITE COMPOSITE

摘要

One of the key fields of biomaterial is artificial bone material. Among various bone-repair and bone-substitute materials, collagen-hydroxyapatite composite has been inspiring the interests of scientists and engineers owning to its superior biocompatibility and biodegradation. However, difficult molding, the poor mechanical strength and the inconformity of degradation rate to osteogenesis progress, these problems limited its actual value. To overcome above problems, based on collagen-hydroxyapatite composite, a novel collagen-hydroxyapatite-microcrystalline cellulose (CHA-MCC) biomaterial was prepared by in-situ method, dehydrothermal treatment (DHT), blending, ultrasonic dispersion method, freeze-drying and cold isostatic compaction technique. Results of scanning electron microscope (SEM) and porosity measurement show that the novel CHA-MCC has irregular porous micro structure, with diameters about 150±50nm and porosities above 70%, which is benefit to osteogenesis. Hydrophilicity and swelling property of this material were also investigated. It is found that the composites prepared are hydrophilic and can swell in simulated body fluid. Besides, the addition of microcrystalline cellulose further improves the mechanical properties of sponges, reaching to 99.05±1.74 MPa, and regulates the degradation rate effectively. These results suggests that this novel CHA-MCC biomaterial could be a promising candidate in bone tissue engineering.