Tissue Fragmentation Treatment by Pulsed Cavitational Ultrasound Therapy-Histotripsy

摘要

Our recent studies have shown that high intensity pulsed ultrasound can achieve mechanical tissue fragmentation ("histotripsy"). Histotripsy has many medical applications where non-invasive tissue removal or remodeling is needed (e.g., cancer therapy). The primary aim of this study is to investigate the level of cellular fragmentation within the region treated by histotripsy and to characterize the boundary between the treated and untreated tissue using transmission electron microscopy (TEM). This study has clinical implications and may help to further understand the physical mechanism of histotripsy.