Preparation of itraconazole/2-hydroxypropyl-? -cyclodextrin inclusion complexform supercritical antisolvent method and in vitro dissolution behavior

摘要

An inclusion complex of an antifungal drug,itraconazol, with 2-hydroxypropyl-?-cyclodextrin(HP-?-CD) were prepared using a supercriticalantisolvent (SAS) process at temperatures of35～65?And at pressures of 83～140 bar.According to the results of this study, the SASprocess appears to be a promising method for thepreparation of water-insoluble drug/cyclodextrininclusion complexes.