Identification the mathematical model of the transmission TB/HIV co-infection in endemic areas

摘要

The mathematical model of the spread of TB and HIV co-infection is theoretically investigated. The sensitivity analysis is carried out based on eigenvalue method for the Hessian of sensitivity matrix. Numerical results are shown that six parameters (from 15 available) are identifiable uniquely by the given data only about numbers of infectious TB individuals with and without HIV and full-blown AIDS individuals during at least 3 years. The sensitivity analysis is closed to investigation of linearized inverse problem (parameter identification) for dynamic systems and very important before applying a numerical method for solving arising inverse problem.