摘要:ObjectiveBy studying acupuncture at Neiguan (PC6), Shuigou (GV26), and Baihui (GV20) in septic shock patients, to observe the effect of acupuncture on T cell subsets, vital signs, white blood cell (WBC) count, and procalcitonin (PCT) level in septicshock patients.MethodSixty patients were randomized into a treatment group and a control group. The control group was intervened by symptomatic managements including supplementing blood volume, anti-inflammation, nutrition support, and organ protection, and the treatment group was by acupuncture at Neiguan, Shuigou, and Baihui in addition to the intervention given to the control group. The T cell subsets contents were detected before and after intervention, and serum PCT level, APACHEⅡscore, vital signs, and WBC count were determined on day 1, 3, 5, and 7.ResultIn the treatment group, T cell subsets including CD3﹢, CD4﹢, and CD4﹢/CD8﹢increased significantly after intervention (P<0.01,P<0.05), while CD8﹢dropped significantly afterintervention (P<0.05), and the changes in the treatment group were all markedly superior to that in the control group (P<0.05). The decrease of PCT level in the treatment group was more significant than that in the control group after treatment, the PCTlevel dropped significantly on the 5th day in the treatment group compared to that before treatment, and the inter-group difference was statistically significant after the 3rd day (P<0.01); the APACHEⅡscore in the treatment group was different from that in the control group after 3 d treatment, and the score was significantly changed in the treatment group after 5 d treatment (P<0.05); the body temperature, heart rate, inspiration, WBC count all showed decrease or improvement, and the improvements of vitalsigns in the treatment group were more significant than that in the control group (P<0.01,P<0.05).ConclusionAcupuncture at Baihui, Shuigou, and Neiguan can improve the immune function of septic shock patients, and its treatment effect is confirmed.%目的:通过对感染性休克患者进行针刺内关、水沟、百会穴治疗的研究,观察其对感染性休克患者的T细胞亚群、生命体征和白细胞数值及PCT水平的影响。方法将60例患者随机分为治疗组和对照组,对照组给予补充血容量、抗感染、营养支持、保护脏器等常规对症支持治疗,治疗组在对照组基础上针刺内关、水沟、百会穴,观察两组患者治疗前后的T细胞亚群含量,测定第1、3、5、7天血清中PCT数值和APACHEⅡ评分及各项生命体征变化和白细胞数值。结果治疗组T细胞亚群中CD3﹢、CD4﹢、CD4﹢/CD8﹢比值与干预前相比明显提高(P<0.01,P<0.05),CD8﹢水平与干预前比较明显下降(P<0.05),且均优于对照组(P<0.05)。治疗组治疗后PCT较对照组下降趋势明显,5 d后较治疗前有明显下降,且第3天后两组之间差异具有统计学意义(P<0.01);治疗组患者治疗3 d后APACHEⅡ评分较对照组有差异(P<0.05),5 d后较治疗前有明显下降(P<0.05);治疗组和对照组患者治疗后体温、心率、呼吸、白细胞计数均有下降或好转,治疗组生命体征指标改善情况均明显优于对照组(P<0.01,P<0.05)。结论针刺百会、水沟、内关穴可提高感染性休克患者免疫功能,并且有确切的治疗效果。