摘要：
Objective To investigate the clinical features of latent autoimmune diabetes in adults (LADA) with albuminuria and relationship between albuminuria with atherosclerosis. Methods A total of 166 hospitalized patients with LADA were recruited in Shanghai Jiaotong university affiliated sixth people's hospital from January 2007 to June 2009. According to the result of albuminuria, all subjects were divided into two groups, such as LADA without albuminuria group (n=142) and LADA with albuminuria group (n=24). The clinical data were collected and analyzed, including diabetes duration, smoking history, drinking history, medications, height, weight, waistline circumference, hip circumference, blood pressure, plasma glucose, blood lipids, C-peptide, renal function and liver function. The clinical features between two groups were compared and the relationship between albuminuria and atherosclerosis was also analyzed. Results Compared with the LADA without albuminuria group, the age of patients in LADA with albuminuria group was older, after adjustment for age and sex, the patients had longer duration of diabetes, higher prevalence of hypertension, higher proportion of using antihypertensive drugs, and higher systolic blood pressure, creatinine, serum uric acid, 24 h of urinary albumin, triglyceride, and 2 h postprandial C-peptide (P 0.05). Binary logistic regression analysis showed that albuminuria was an independent risk factor for atherosclerosis in LADA patients (P0.05) .二元Logistic回归分析显示, 蛋白尿是LADA患者发生AS的独立相关因素 (P<0.05) .结论 LADA伴蛋白尿患者较不伴有蛋白尿患者AS斑块和动脉狭窄的患病率更高, 可能与其代谢紊乱更加严重有关, 而蛋白尿是LADA患者发生AS的独立相关因素.
