摘要:
目的 研究23种HPV基因亚型在天津地区女性中的感染状况以及亚型分布特征,为预防HPV感染和宫颈癌防治提供依据.方法 利用DNA杂交技术检测妇科门诊样本,并进行基因分型,比较不同亚型流行病学的特点.结果 3350例样本中HPV感染者l 048例,感染率为31.28%,其中高危亚型检出652例,占感染者的62.21%,低危亚型229例,占21.85%,同时感染高危亚型和低危亚型的167例,占15.93%.各年龄组均以单重感染为主,其次为二重感染.在5个年龄组中,≤25岁年龄段感染比例最高.23个亚型中以16型最多,其次为58型和56型.结论 天津地区女性HPV感染以单重感染为主,高危亚型的感染具有一定优势;高危亚型中,HPV16、58和56为主要感染亚型.%Objective To study the prevalence and molecular epidemiological characteristics of 23 genotypes of human apillomavirus (HPV) inTianjin,and to provide theoretical basis for preventing and treating uterine cervical cancer.Methods All samples were detected for HPV genotypes by using DNA hybridization technique,and the molecular epidemiological characteristics of 23 HPV types were compared.Results Among the 3 350 samples,1 048 cases were HPV,with the positive rate of 31.28%; 652 cases belonged to high-risk type only,accounting for 62.21% of HPV positive cases; 229 (21.85%) cases belonged to low-risk type,while 167 (15.93%) cases were mixed with high-risk type and low-risk type.Subtype HPV16 occupied the first of all high-risk types,followed by subtype HPV58 and HPV56.The most common HPV infection in 5 age groups was single genotype,followed by double HPV genotypes.Compared with other age groups,the infection rate of the group with age ≤25 years old was the highest.HPV16 genotype was the most common HPV infection type,and HPV58 and HPV56 are the major subtypes.Conclusion The most common HPV infection is single genotype in Tianjin.The predominate high risk subtype are HPV16,HPV58 and HPV56.