摘要：
1.Sirong He1,Dan Shi2,Zhigang Han3,Zhaoming Dong4,5,Yajun Xie6,Fengmei Zhang3,WenXin Zeng3 and Qiying Yi3(1.Department of Immunology,College of Basic Medicine,Chongqing Medical Univer⁃sity,Chongqing,400016,China;2.Intervention Sec⁃tion,Chinese Medicine Hospital of Dianjiang County,Chongqing,408300,China;3.Laboratory Animal Center,Chongqing Medical University,Chongqing,400016,China;4.Biological Science Research Cen⁃ter,Southwest University,Chongqing,400716,China;5.Chongqing Engineering and Technology Research Center for Novel Silk Materials,Southwest University,Chongqing,400716,China;6.The M.O.E.Key Labo⁃ratory of Laboratory Medical Diagnostics,The College of Laboratory Medicine,Chongqing Medical Universi⁃ty,Chongqing,400016,China).Heparinized silk fi⁃broin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision.Bio⁃Medical Engineering OnLine,2019,18(1):97.题目:加载FGF1的肝素化丝素蛋白水凝胶可促进全层皮肤切除大鼠的伤口愈合摘要:蚕茧丝素蛋白水凝胶具有良好的生物相容性、免疫原性和生物可降解性,对伤口愈合具有潜在的作用。许多研究表明,丝素蛋白是一种很有前途的创面敷料,可以在体外支持多种人细胞的黏附和增殖。然而,由于缺乏相应的体内试验证据,限制了其在皮肤修复中的临床应用。本文采用全层皮肤切除模型大鼠,在其创面敷上加注了人酸性成纤维细胞生长因子1(human acid fibroblast growth factor 1,FGF1)的肝素化丝素蛋白水凝胶,以充分评价其创口愈合效果、安全性和有效性等临床前试验指标,并与临床应用的壳聚糖进行比较。结果显示,敷在创面上加注了FGF1的肝素化丝素蛋白水凝胶具有很好吸水性能,在12 h内能迅速膨胀至最大的17.3倍,并且在15 d内可损失凝胶总量的40.48±1.28%,同时FGF1能被有效释放;加注了FGF1的肝素化丝素蛋白水凝胶能引起创面真皮形成和胶原沉积。
