cycle

摘要： Mitochondria dysfunction occurs in the aging brain as well as in several neurodegenerative disorders and predisposes neuronal cells to enhanced sensitivity to neurotoxins.In particular,defects in any of the mitochondria respiratory chain complexes lead to impaired adenosine triphosphate production resulting in diseases that often affect the central nervous system.For instance,innate deficits in succinate dehydrogenase(SDH)mitochondria respiratory chain complex II activity caused by genetic mutations in SDH subunits lead to early-onset neurodegeneration(Jain-Ghai et al.,2013),while several adult-onset genetic neurodegenerative disorders are associated with variable levels of complex II deficiency in the central nervous system(Túnez et al.,2010).Also,chemically induced complex II deficiency leads to neurodegeneration.

摘要： The brain is an expensive tissue in terms of energy consumption.It composes about 2%of body mass and consumes about 20%of all oxygen and calories(Fedorovich and Waseem,2018).For neurons,glucose is the primary energy substrate,although they are able to use ketone bodies,pyruvate and lactate(Fedorovich and Waseem,2018).All these compounds can be metabolized directly in the Krebs cycle,bypassing glycolysis.Hence,they are often termed non-glycolytic energy substrates.Out of all potential non-glycolytic substrates,lactate is the most physiological(Magistretti and Allaman,2018).Ketone bodies could reach concentrations in blood plasma and cerebrospinal fluid which are sufficient to meet metabolic demands of neurons only under specific non-physiological conditions,e.g.,ketogenic diet and starvation,or during suckling.In contrast,the normal plasma level of lactate is about 1.5 mM and can reach 20 mM during intensive physical exercise.

摘要： People all across the world are getting vaccinated against the virus as Coronavirus Disease 2019(COVID-19)spreads.The possibility of adverse reactions to COVID-19 vaccinations has always been a source of concern[1-4].It is also unclear whether COVID-19 immunizations impact female vaccinators’menstrual cycles.Unfortunately,menstrual cycle outcomes were not collected in clinical studies of the current COVID-19 vaccines[1-4].The menstrual cycle of a woman runs from the first day of her menstruation to the first day of her next cycle.Many factors,including nutrition,sleep,and exercise,as well as illness,travel,and stress,are known to influence the length of the menstrual cycle[5].COVID-19 vaccines have caused a variety of side effects in people,including pain at the injection site,nausea,aches,fever,and fatigue.

摘要： The authors regret that the printed version of the above article contained some errors.The funding number in acknowledgments of this paper was incorrectly marked,and we hope to correct it.We thank the National Natural Science Foundation of China(51764048,51703118 and 51474191),Yunnan Province Thousand Youth Talents Plan,the Application Basis Research Project of Yunnan Province Science and Technology Department(2017FD144)and Key Natural Science Foundation of Yunnan Province China(2018FA28)for providing the financial support.

摘要： Dear Editor,Taisui(太岁) has attracted great attention in China because it has been described in ancient Chinese texts as an entity possessing mysterious properties. In Chinese mythology and folklore, Jupiter is the God of the "Sui"(year) and is worshiped in Daoism. Jupiter appears at the same location in the sky approximately every 12 years(Jupiter’s orbit is11.86 years). However, since each cycle of Jupiter lasts for exactly 11.86 years and one Chinese year cycle comprises exactly 12 years, after approximately 84.7 years, Jupiter travels one cycle more than the number of cycles assumed by the ancient Chinese, which is called Taisui. According to the belief of the ancient Chinese, people are alerted when Taisui is digging in the ground, foretelling the destruction of houses or occurrence of natural disasters, such as floods and earthquakes(Zhao et al., 2018).

摘要： Dear Editor,Chinese cordyceps, a valuable Chinese traditional medicine, is a complex of mummified ghost moth caterpillars and fungal stroma of Ophiocordyceps sinensis (Winkler, 2010). O. sinensis has been nominated as the national fungus of China and flagship species of the Tibetan Plateau (Cannon, 2010;Zhang et al., 2012).

摘要： BACKGROUND Esophageal cancer is a common digestive tract tumor that is generally treated with radiotherapy.Poor responses to radiotherapy in most patients generally result in local radiotherapy failure,so it is essential to find new radiosensitizers that can enhance the response of cancer cells to radiotherapy and improve the survival of esophageal cancer patients with radiation resistance.The long noncoding RNA(lncRNA)Rpph1 is highly expressed in human gastric cancer tissues,and represses breast cancer cell proliferation and tumorigenesis.However,the expression of lncRNA Rpph1 in esophageal cancer and its relationship with radio-sensitivity has not been studied.AIM To explore the value of lncRNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy.METHODS Eighty-three patients with esophageal cancer admitted to Qilu Hospital of Shandong University and 90 healthy participants who received physical examinations were collected as research participants.The expression of Rpph1 was determined by qRT-PCR.siRNA-NC and siRNA-Rpph1 were transfected into esophageal cancer cell lines,and cells without transfection were designated as the blank control group.Cell survival was tested by colony formation assays,and the levels of proteins related to apoptosis and epithelial-mesenchymal transitions were determined by Western blot assays.Cell proliferation was assessed by MTT assays,cell apoptosis by flow cytometry,and cell migration by wound-healing assays.Changes in cell cycle distribution were monitored.RESULTS Rpph1 was highly expressed in esophageal carcinoma,making it a promising marker for the diagnosis of esophageal cancer.Rpph1 could also be used to distinguish different short-term responses,T stages,N stages,and clinical stages of esophageal cancer patients.The results of 3-year overall survival favored patients with lower Rpph1 expression over patients with higher Rpph1 expression(P<0.05).In vitro and in vivo experiments showed that silencing Rpph1 expression led to higher sensitivity of esophageal cancer cells to radiotherapy,stronger apoptosis in esophageal cancer cells induced by radiotherapy,higher expression of Bax and caspase-3,and lower expression of Bcl-2(Bax,caspase-3,and Bcl-2 are apoptosis-related proteins).Additionally,silencing Rpph1 attenuated radiation-induced G2/M phase arrest,and significantly inhibited the expression of proteins involved in cell proliferation,migration,and epithelial-mesenchymal transition regulation in esophageal cancer cells.CONCLUSION Rpph1 is highly expressed in esophageal cancer.Silencing Rpph1 expression can promote cell apoptosis,inhibit cell proliferation and migration,and increase radio-sensitivity.

摘要： 本发明涉及一种针对具有重复运动特性的被控系统跟踪误差的Cycle to Cycle反馈控制补偿方法，具体涉及基于Cycle to Cycle反馈控制的数控凸轮磨削轮廓误差补偿控制方法。以解决数控凸轮磨削传统控制方法存在的仅利用当前磨削周期的信息而忽略之前磨削周期信息的问题，提高数控凸轮磨削的轮廓精度。CtC反馈控制是在逐次循环过程控制之间利用上一个周期的磨削信息即轮廓误差来指导本周期的磨削过程。通过系统动态与稳态特性分析，优化CtC反馈控制器参数，使得磨削轮廓误差控制在允许的范围之内，得到满意的磨削精度。本发明引入Cycle to Cycle理论，提出了凸轮在磨削过程中的轮廓精度补偿方法和计算步骤，使补偿有理论依据，改变了目前补偿凭经验的现状。

摘要： 本发明公开了一种xPON终端和机顶盒Power Cycle测试系统及测试方法，它包括测试PC、单片机和自动开关板；所述的测试PC内置有主控程序，所述的单片机中内置有单片机程序；所述的单片机程序实现控制继电器进行AC或者DC的通断，进而对待测试设备DUT进行开关发现隐患问题点；测试PC中的主控程序通过通信串口对所述自动开关板进行多重控制，实现控制自动开关板进行开关机，对连接的DUT的LAN口以及WLAN口进行ping包并统计和记录，以及控制运行另外接至待测试设备DUT的串口以记录DUT的启动信息。本发明的优点在于：通过单片机程序以及主控程序控制两种通断电方式对待测试设备DUT进行测试，相比于人工测试具有效率高，测试准确以及测试成本低的特点。

摘要： 本发明提供一种基于Cycle‑Seq2Seq的开放域对话生成方法，该方法包括：基于正向任务input‑to‑response和反向任务response‑to‑input建立Cycle‑Seq2Seq模型，所述正向任务input‑to‑response和反向任务response‑to‑input都使用一个NCG模型去完成对应的任务目标，正向任务input‑to‑response对应的NCG模型任务目标为根据用户的输入生成相应的回复，反向任务response‑to‑input对应的NCG模型任务目标为根据问答的回复生成可能的用户输入；对正向任务和反向任务迭代进行联合训练，共同优化联合任务的目标，每次迭代通过模型更新优化生成更准确的input‑to‑response句子和response‑to‑input句子，在联合训练过程中通过交替迭代生成质量更高的训练数据。所述方法使用较少的语料就能够训练出性能较高的模型，生成的对话内容关联性强。

摘要： 本发明公开了一种基于改进Cycle GAN的图像生成方法，包括从X域图像数据库中获取输入图像；将所述输入图像输入至编码器并输出特征图像；将所述特征图像输入至特征权重自适应模块，对所述特征图像提取背景信息和目标特征信息，并针对提取的背景信息和目标特征信息进行不同权重的特征融合；将处理后的特征图像依次输入至转换器和解码器中还原生成输出图像。本发明的图像生成方法将特征融合机制引入Cycle GAN网络，改进后生成的图像效果更加真实，特征细节处理效果更好，且改善了原网络转换后背景失真问题，使得转换后的图像在结构、亮度和色彩上更加接近于真实场景下的图像。

摘要： 本发明涉及一种针对具有重复运动特性的被控系统跟踪误差的Cycle to Cycle反馈控制补偿方法，具体涉及基于Cycle to Cycle反馈控制的数控凸轮磨削轮廓误差补偿控制方法。以解决数控凸轮磨削传统控制方法存在的仅利用当前磨削周期的信息而忽略之前磨削周期信息的问题，提高数控凸轮磨削的轮廓精度。CtC反馈控制是在逐次循环过程控制之间利用上一个周期的磨削信息即轮廓误差来指导本周期的磨削过程。通过系统动态与稳态特性分析，优化CtC反馈控制器参数，使得磨削轮廓误差控制在允许的范围之内，得到满意的磨削精度。本发明引入Cycle to Cycle理论，提出了凸轮在磨削过程中的轮廓精度补偿方法和计算步骤，使补偿有理论依据，改变了目前补偿凭经验的现状。

摘要： 本发明公开了一种基于改进Cycle GAN的图像生成方法，包括从X域图像数据库中获取输入图像；将所述输入图像输入至编码器并输出特征图像；将所述特征图像输入至特征权重自适应模块，对所述特征图像提取背景信息和目标特征信息，并针对提取的背景信息和目标特征信息进行不同权重的特征融合；将处理后的特征图像依次输入至转换器和解码器中还原生成输出图像。本发明的图像生成方法将特征融合机制引入Cycle GAN网络，改进后生成的图像效果更加真实，特征细节处理效果更好，且改善了原网络转换后背景失真问题，使得转换后的图像在结构、亮度和色彩上更加接近于真实场景下的图像。

摘要： 本发明针对现有技术的局限性，提出了一种基于Cycle‑GAN与ResNeXt的蔬菜病害识别方法，该方法使用了基于深度学习网络ResNeXt的模型进行病害叶片的识别，还以包括现有公开数据、人工采集数据以及由基于Cycle‑GAN的模型生成的伪数据在内的混合数据集来展开模型训练，提高了模型的泛化性；本发明方案的识别结果精细化程度以及准确率更高，具备更好的实际应用价值。

摘要： 本发明涉及酒瓶表面包装工艺生产技术领域,尤其是一种基于Cycle‑Gan的酒瓶表面缺陷样本生成方法，首先采集并分析某一种酒瓶的表面缺陷样本集；随后在采集整理好的缺陷样本集基础上利用Cycle‑Gan网络生成酒瓶表面缺陷样本；最后搭建YOLOX检测网络验证生成缺陷图像用于扩充的有效性。本发明提出了一种基于循环一致性生成对抗网络(Cycle‑Gan)的酒瓶表面缺陷图像生成方法来生成大量缺陷样本以满足目标检测神经网络模型训练使用的要求。实验表明，随着数据集规模的提升以及各缺陷形状的样本数量趋于均匀，检测网络性能同比有效增长，验证了基于Cycle‑Gan的酒瓶缺陷生成样本的有效性。

摘要： 本发明公开了一种基于Cycle‑GAN和在线特征迁移的轴承剩余寿命预测方法，涉及球轴承技术领域；基于Cycle‑GAN网络和在线特征迁移的轴承剩余寿命预测方法包括以下步骤：步骤一、构建改进型Cycle‑GAN网络，轴承振动数据进行小波变换预处理，进行重构特征增强，然后再将其输入到网络中，通过对抗训练生成大量振动数据样本；步骤二、将生成的振动数据样本混合到真实振动数据样本中，再将混合后的样本数据输入CNN网络进行特征提取，由LSTM输出层进行寿命预测，并对输出数据做滑窗处理平滑曲线，最终实现轴承的寿命预测；步骤三、基于已训练的Cycle‑GAN网络，研究基于特征自适应的在线迁移方法，利用源域网络模型中的特征进行迁移学习，实现目标域数据集的轴承剩余寿命预测。

摘要： 本发明提供一种基于Cycle‑GAN的DU‑GAN双能CT超分辨方法。该方法包括：构建DU‑GAN网络模型，具体包括：采用Cycle‑GAN网络作为模型框架，并对Cycle‑GAN网络中的生成器和判别器均引入U‑Net网络框架；构建数据集并将数据集划分为训练集、测试集和验证集；设计图像域损失函数以构建联合损失函数，所述联合损失函数由对抗性损失函数、循环一致性损失函数和图像域损失函数组成；将训练集输入DU‑GAN网络模型，通过联合损失函数进行有监督网络训练，并用验证集对训练的DU‑GAN网络模型的性能进行评估；将测试集中低分辨率双能CT图像输入训练好的生成器得到相应的超分辨双能CT图像。本发明可以有效抑制低分辨率CT图像的伪影，恢复图像的细节信息，提高图像质量，在一定程度上提高双能CT分辨率。