Tablet

摘要： BACKGROUND Enteric-coated medications are supposed to pass intact through the gastric environment and to release the drug content into the small intestine or the colon.Before dissolution of the enteric coating,they may appear hyperdense on computed tomography(CT).Unfortunately,few reports have been published on this topic so far.In this case report,the hyperdense appearance on contrastenhanced CT of an enteric-coated mesalamine tablet was initially misinterpreted as a jejunal gastrointestinal stromal tumor(GIST).CASE SUMMARY An asymptomatic 81-year-old male patient,who had undergone laparoscopic right nephrectomy four years earlier for stage 1 renal carcinoma,was diagnosed with a jejunal GIST at the 4-year follow-up thoraco-abdominal CT scan.He was referred to our hub hospital for gastroenterological evaluation,and subsequently underwent 18-fluorodeoxyglucose positron emission tomography,abdominal magnetic resonance imaging,and video capsule endoscopy.None of these examinations detected any lesion of the small intestine.After reviewing all the CT images in a multidisciplinary setting,the panel estimated that the hyperdense jejunal image was consistent with a tablet rather than a GIST.The tablet was an 800 mg delayed-release enteric-coated oral mesalamine tablet(Asacol®),which had been prescribed for non-specific colitis,while not informing the hospital physicians.CONCLUSION Delayed-release oral mesalamine(Asacol®),like other enteric-coated medications,can appear as a hyperdense image on a CT scan,mimicking a small intestinal GIST.Therefore,adetailed knowledge of the patients’medications and a multidisciplinary review of the images areessential.

摘要： Social media has changed the way we learn,educate,and interact with our peers.The dynamic nature of social media and their immediate availability through our portable devices(smartphones,tablets,smartwatches,etc.)is quickly transforming the way we participate in society.The scope of these digital tools is broad as they deal with many different aspects:Teaching and learning,case discussion,congresses coverage,peer to peer interaction,research are examples worth mentioning.The scientific societies considered more innovative,are promoting these tools between their members.These new concepts need to be known by the cardiologists to stay updated,as countless information is moving rapidly through these channels.We summarize the main reasons why learning how to use these tools to be part of the conversation is essential for the cardiologist in training or fully stablished.

摘要： The core objective of the current work was to improve dissolution rate of poorly water-soluble anti-diabetic drug gliclazide by solid dispersions (SDs) technique using fumed silica particles Aerosil 380 as carrier into compressed tablets. Different FGA-1, FGA-2, FGA-3 (Formulated Gliclazide Aerosil;weight ratio, 1:1) and FPG-1, FPG-2 (Formulated Plain Gliclazide) tablet batches were formulated, prepared, evaluated and characterized. All the findings of pre-compression factors were found to be satisfactory and post-com- pression parameters revealed good mechanical integrity and good uniformity in all formulations. All the formulated tablets satisfied the compendia limits of weight variation, friability and the disintegration time. Among all formulations, FGA-3 was optimized based on in vitro drug release findings, disintegration time, hardness and other quality attributes. The percent of drug release from the formulated FGA tablets containing gliclazide loaded aerosil is about 3 fold higher when compared with the tablets formulated and prepared with plain gliclazide (FPG) and the tested commercial brands in first 60 minutes. There was no significant change noted in the drug content and drug release pattern in the FGA tablets batches when stored in 40°C?and 75% RH for three months. It was thus concluded that SDs formulations of gliclazide could be successfully used to design and develop a solid dosage form of the drug, which would have significant benefits over the existing commercial brands.

摘要： We established a monolayer polarized cell model using human kidney 2 (HK-2) cells cultured in a transwell chamber to examine the changes in the morphology and physiological functions of human-derived renal proximal tubular epithelial cells caused by tripterygium tablet extract (TTE) and triptolide. HK-2 cells were cultured on PCF membranes to form a complete monolayer of cells. A MTT assay was used to select 10, 40, 160, 640 μg·ml-1 TTE or 4, 16, 64, 256 ng·ml-1 triptolide to treat HK-2 monolayer cells. After 24 hours, a FITC permeability assay was performed;GGT, LDH and NAG secretion on the apical (AP) and basolateral (BL) sides of the cells by HK-2 cells were examined. The morphology and the monolayer structure of HK-2 cells was observed via optical microscope and scanning electron microscope, respectively. The effect on the cytoskeleton of HK-2 cells was observed under a fluorescence microscope. The IC50 of TTE was 277.122 μg·ml-1, and the IC50 of triptolide was 148.035 ng·ml-1. Compared with the DMSO group, the FITC leakage rate with TTE 160, 640 μg·ml-1 treated group and 4 - 256 ng·ml-1 triptolide dose group exhibited statistically significant increase. TTE significantly increased secretion of GGT and LDH at 160, 640 μg·ml-1, meanwhile, dramatically increased the AP/BL ratio of LDH at 160 μg·ml-1;triptolide significantly increased secretion and AP/BL ratio of GGT and LDH at 256 ng·ml-1. The morphological observations via optical and electron microscope indicated various degrees of damage to HK-2 cells by TTE and triptolide, and the degree of damage correlated positively with the dosage of the tested articles. Compared with DMSO group, the cellular damage degrees at TTE dosages of 40 - 640 μg·ml-1 and triptolide dose group at 16, 256 ng·ml-1 exhibited statistically significant differences via observation under optical microscope. Both TTE and triptolide caused various degrees of shortening and thickening of intracellular F-actin bundles of HK-2 cells;aggravation of these changes was observed with increasing drug dosage. Thus, we conclude both TTE and triptolide caused damage to human renal proximal tubular epithelial cells at certain dosages;TTE dosages of 40 μg·ml-1 and above and triptolide dose group at 16 ng·ml-1 and above exhibited the changes in the morphology, meanwhile, TTE dosages of 160 μg·ml-1 and above and triptolide dose group at 256 ng·ml-1 exhibited the changes in the physiological functions such as secretion of HK-2 cell.

摘要： 2017年2月7日，北欧豪华汽车品牌沃尔沃汽车宣布：携手全球高端精品酒店预订网站Tablet Hotels，打造全新“GetAway Lodge”度假产品。在特定时间内，用户在途泊在线预定“Get Away Lodge”私人订制度假产品，即可在瑞典北部滑雪胜地奥勒。

摘要： The phenomenon of car-following is special in traffic operations. Traditional car-following models can well describe the reactions of the movements between two concessive vehicles in the same lane within a certain distance. With the invention of connected vehicle technologies, more and more advisory messages are in development and applied in our daily lives, some of which are related to the measures and warnings of speed and headway distance between the two concessive vehicles. Such warnings may change the conventional car-following mechanisms. This paper intends to consider the possible impacts of in-vehicle warning messages to improve the traditional car-following models, including the General Motor (GM) Model and the Linear (Helly) Model, by calibrating model parameters using field data from an arterial road in Houston, Texas, U.S.A. The safety messages were provided by a tablet/smartphone application. One exponent was applied to the GM model, while another one applied to the Linear (Helly) model, both were on the stimuli term “difference in velocity between two concessive vehicles”. The calibration and validation were separately conducted for deceleration and acceleration conditions. Results showed that, the parameters of the traditional GM model failed to be properly calibrated with the interference of in-vehicle safety messages, and the parameters calibrated from the traditional Linear (Helly) Model with no in-vehicle messages could not be directly used in the case with such messages. However, both updated models can be well calibrated even if those messages were provided. The entire research process, as well as the calibrated models and parameters could be a reference in the on-going connected vehicle program and micro/macroscopic traffic simulations.

摘要： OBJECTIVE To investigate the prevention and its mechanism of Naojian Tablet,the adjusted prescription from Buyang Huanwu Decoction,during focal ischemic brain injury condition,and study on the main bioactive substance for this function.METHODS To apply the modified middle cerebral artery occlusion(MCAO)model in rats,immunohistochemistry,RT-PCR and Western blotting were applied to determine the expression of CDK5,CDK4/cyclinD1 in the hippocampus tissues in MCAO rat by treating with Naojian Tablet.On the other hand,the processes of metabolism and disposition of several active components in Naojian Tablet and Buyang Huanwu Decoction were analyzed and characterized by using HPLC-Q-TOF method.RESULTS Naojian Tablet(ig,2.41g·kg-1)could significantly decrease the levels of CDK5,CDK4/cyclinD1 in hippocampus tissues in MACO rat after treated by 3d,7d,14 d,28d(P<0.05).The similar mechanism was observed in the Buyang Huanwu Decoction treated MACO rat.Calycosin,fermononetin,senkyunolide and ligustilide in Naojian Tablet was determined simultaneously as the main active ingredient of Naojian Tablet.CONCLUSION The above-mentioned in vivo studies suggested that Naojian Tablet maybe play its prevention effect on nerve cells via its acting on CDK5 signaling and cell cycle pathway,which verified the multi-target and multi active pathways efficiency of tradition Chinese medicine in treating diverse disease.

摘要： In this paper, an internal multiband antenna is proposed for LTE-A/WWAN wireless applications in tablet computer. The proposed antenna is configured to have two branch radiators. These two branch radiators are a U-shaped driven monopole and a nonuniform wrapped inverted U-shaped monopole. The impedance bandwidths across dual operating bands are 89.7 MHz and 4185 MHz at the LTE-A/WWAN bands. Various techniques, such as branching and parasitic element are used to enhance the antenna’s bandwidth, the matching, and the size of the proposed antenna. The antenna is presented on an area of 50 × 15 mm2. Experimental results of this antenna show nearly omni-directional coverage and stable gain variation across the LTE-A/WWAN bands.

摘要： 索尼在9月3日的柏林电子消费展会上公布了旗下XperiaZ3系列的最新产品。三款产品分别为8英寸的平板电脑——Xperia Z3 Tablet Compact、旗舰品牌手机——XperiaZ3以及对应的轻巧型号手机——XperiaE3。

摘要： 强悍来自骁龙芯当前平板电脑采用的处理器大致分为两派，一派是采用被应用在旗舰级智能手机上的移动处理器，另一派则是采用低功耗电脑处理器，对索尼来说，采用手机版移动处理器的好处是可以将Xperia系列的形象统一，同时还可兼顾性能和电池续航时间的矛盾。在具体的选择上，XperiaZ2Tablet采用了当前性能最为强劲的高通骁龙801（MSM8974AB）处理器，频率高达2．3GHz，不仅能流畅地播放1080p全高清视频，甚至还能通过硬件解码流畅地播放4K分辨率视频。

摘要： 一种适用于笔记本和Tablet的宽带LTE天线，包括PCB板以及设置于其上方的天线部分，PCB板分为金属区域与非金属区域；所述天线部分设置在非金属区域内，所述天线部分包括低频寄生臂和高频寄生臂，所述低频寄生臂和高频寄生臂平行于PCB板的长边设置；所述低频寄生臂和高频寄生臂设置于非金属区域靠外的边缘部，所述低频寄生臂和高频寄生臂相互隔离并都与PCB板联通；所述天线部分包括馈电分支，所述馈电分支分为馈电分支一与馈电分支二，所述馈电分支一与馈电分支二垂直设置，所述馈电分支一与馈电分支二一体制成；这种天线结构简单，具有宽带，效率高的特点。

摘要： 一种适用于笔记本和Tablet的宽带LTE天线，包括PCB板以及设置于其上方的天线部分，PCB板分为金属区域与非金属区域；所述天线部分设置在非金属区域内，所述天线部分包括低频寄生臂和高频寄生臂，所述低频寄生臂和高频寄生臂平行于PCB板的长边设置；所述低频寄生臂和高频寄生臂设置于非金属区域靠外的边缘部，所述低频寄生臂和高频寄生臂相互隔离并都与PCB板联通；所述天线部分包括馈电分支，所述馈电分支分为馈电分支一与馈电分支二，所述馈电分支一与馈电分支二垂直设置，所述馈电分支一与馈电分支二一体制成；这种天线结构简单，具有宽带，效率高的特点。