receptor

摘要： Background: Based on the effect of seasonal changes on human visceral function, this study investigated the impact of seasonal photoperiod of the pineal body on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in rats, aiming to reveal the mechanism by which pineal gland melatonin regulates the seasonal secretion of hippocampal neurotransmitters.Methods: Vernal equinox, summer solstice, autumn equinox, and winter solstice were selected as four experimental time points, and rats were randomly divided into normal control group, sham operation group, and pinealectomized group. The seasonal changes in corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH), corticosterone, hypothalamic melatonin receptor(MTR), and hippocampal corticosterone receptor(CORTR) were examined by enzyme-linked immunosorbent assay.Results: Comparing the same group between different seasons, we showed that in the normal control group, CRH, ACTH, corticosterone, and MTR were higher, while CORTR was lower in autumn and winter than in spring(all P <.05). Compared with the normal control group, the pinealectomized group showed higher levels of corticosterone(P =.01), MTR(P =.01), and CORTR(P =.03) during spring;reduced levels of MTR and CORTR(both P <.001) during summer;higher levels of ACTH(P =.001) and MTR(P <.001),and lower levels of CRH(P =.001), corticosterone(P <.001), and CORTR(P =.003) during autumn;and lower levels of CRH(P <.001) and MTR(P =.004), and higher level of ACTH(P <.001) in winter.Conclusions: Seasonal photoperiod acts on the pineal gland to secrete different levels of melatonin,resulting in seasonal changes in the hypothalamic-pituitary-adrenal axis-hippocampal-receptor, which may be the pathophysiological basis for the onset of seasonal affective disorder.

摘要： Parkinson’s disease(PD)and its treatment had mainly been focused on the Nigro-striatal dopamine(DA)neurons as the major site of degeneration in this disease.It contributed to the search for drugs that restored DA transmission in this pathway and contributed to the introduction of L-DOPA and DA receptor agonists in its treatment(Borroto-Escuela and Fuxe,2019).

摘要： 最近的研究表明血管内皮生长因子受体-3(vascular endothelial growth factor receptor-3,VEGFR-3)在脑膜淋巴管重塑的过程中发挥关键作用。本研究旨在探讨环氧化物酶(cyclooxygenase 2,COX-2)能否通过调节VEGFR3参与Aβ诱导的脑膜淋巴管功能障碍。

摘要： The aim of the present study have been reported to review the estrogen level in the patients with the breast cancer and healthy individuals.Breast cancer is one of the most common diseases in women worldwide that is characterized by uncontrolled growth of malignant cells in the mammary epithelial tissue.The estrogen was found at normal level in most patients with ER-positive breast cancer and in healthy individuals,while its high level was higher among patients with ER-negative breast cancer.Many studies show evidences about the role of estrogen at a high level on the development of breast cancer.The association between the estrogen levels and the presence of Candida spp.in vagina of patients with breast cancer was reviewed.

摘要： This paper designed a detailed procedure for monogenic hypertension diagnosis by Whole Exome Sequencing(WES)and provided reliable precise medication guidance.Identification of mutated points provides the clinician valuable information for effective individualized therapeutic option.Therapeutic options that specifically restore the pathway disturbed by these point mutations can be selected to give a precise medicinal guidance.

摘要： Objective:To evaluate the efficacy and safety of tirofiban hydrochloride in the treatment of ischemic stroke with thrombolytic therapy.Method:Two hundred patients with acute ischemic stroke thrombolysis were randomly divided into the experimental group and the control group.The experimental group was given tirofiban with the addition of rtpa in the control group and the therapeutic effects of the two groups were compared.Results:In comparison with the control group,the NIHSS improvement rate was 98%in the experimental group within 14 days.The platelet aggregation rate and efficacy in the experimental group were significantly reduced than the control group(P<0.01).The major adverse reaction in the two groups was hemorrhage with an incidence rate of 3%.Conclusion:Tirofiban hydrochloride is a highly effective and selective platelet glycoprotein Ⅱb/Ⅲa receptor inhibitor,which is safe and effective in combination with heparin and aspirin.

摘要： Angiotensin II (Ang II) is known to elicit cardiac fibrosis by activating the AT1 receptor and CD44 expression in the in vivo model. However, the cellular/molecular mechanisms underlying cardiac fibrosis are still not well understood. This study examines the roles of the AT1 receptor and CD44 gene expression in collagen synthesis through Ang II stimulated cardiac fibroblasts. Fibroblasts were isolated from the neonatal rat hearts;the activation of fibroblasts was evaluated using the assays of cell viability and migration, and silencing of CD44 gene expression was conducted with small interfering RNA (siRNA). Results showed that Ang II significantly increases the cell proliferation and migration in a dose-dependent manner. Upon activation, the protein levels of TGF-β1, Smad2, Smad4 and collagen I were significantly increased (all p < 0.05 vs. unstimulated cells), but these changes were significantly downregulated by the AT1 receptor blocker, telmisartan (all p < 0.05 vs. Ang II activated cells). Furthermore, mRNA and protein level of CD44 were upregulated, and there was a linear correlation between CD44 and TGF-β1 as demonstrated by Pearson correlation analysis (r = 0.955, p < 0.01). Gene transfection of fibroblasts with Ad-CD44 siRNA, as evidenced by low levels of CD44 mRNA and protein, significantly reduced the production of collagen I. In summary, these results indicate that the proliferation, migration and collagen production from Ang II activated cardiac fibroblasts are potentially mediated by the AT1 receptor and CD44. Such a signaling mechanism could be crucial for the production of collagen and the development of tissue fibrosis in the heart.

摘要： Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of atherosclerosis.However,it is unclear how the above factors interact in this setting.In this study,we investigated the role of P-selectin and its receptor,P-selectin glycoprotein ligand(PSGL)-1 in atherosclerosis,with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in the PGSL-1+DCs group,with CD40 and CD86 expressed by 3.84%and 2.05%for the latter.The highest expression of CD80,CD83,and MHC II was discovered in the DC group,at 7.49%,3.68%,and 8.98%,respectively.Results of this study are similar to those obtained previously by Ye et al.(2017),which showed larger atherosclerotic lesions in mice that received exogenous DCs,compared with those treated with PBS.In this study,the greatest level of atherosclerosis,fibrosis,and lipid deposition was also seen in mice that received exogenous DCs.

摘要： Temperature is a key regulator of brown adipose tissue(BAT)function,acting through central sensory inputs to influence metabolism and energy storage.Although animal models have produced a wealth of information on the pathways,effectors and responses mediating the physiological response of adipose tissue to temperature in vivo,the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes,in the absence of neural input.In particular,stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in vitro.Here the basis for adipogenic responsiveness to low temperature is discussed,together with different human cell models available to outline the benefits of cell-based approaches for future BAT research.

摘要： 美国FDA于2019年4月4日批准辉瑞公司(Pfizer)晚期乳腺癌治疗药物Ibrance(palbociclib,0x09帕博昔布,CAS登记号:571190-30-2)胶囊扩大适用证(适用症)范围,可与其他特定的内分泌治疗药物联用,用于男性治疗激素受体(HR)阳性及人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阴性晚期或者转移性乳腺癌。

摘要： 本发明提供了一种中黑盲蝽insulin receptor substrate 1基因及其应用，属于昆虫基因工程技术领域。本发明所述基因的核苷酸序列如SEQ ID NO.1所示。本发明还设计了所述基因的RNA干扰序列，所述干扰序列dsRNA对中黑盲蝽insulin receptor substrate 1基因具有良好的沉默效果。注射该干扰序列，显著降低了中黑盲蝽卵巢的挂卵量，抑制了中黑盲蝽的产卵量，最终导致了中黑盲蝽的生殖能力下降，可以有效的控制其种群的发展，可用于转基因抗虫植物的开发以及中黑盲蝽的生物防治。

摘要： 本发明公开了一种Toll-like receptor-3(TLR3)激动剂在制备促进伤口愈合的药物中的应用。Toll-like receptor-3(TLR3)激动剂能够促进伤口的愈合，可作为促进伤口愈合的药物的活性成份，特别是polyriboinosinic polyribocytidylic acid，其能显著的缩短皮肤或者粘膜伤口的愈合时间，在临床治疗中，无搔痒、红肿热痛或其他不良反应，愈合后无明显瘢痕及皮肤质地改变，愈合质量高。本发明的polyriboinosinic polyribocytidylic acid有望作为正常个体、伤口难愈的个体或整形美容外科的伤口愈合的常规用药。

摘要： 本发明提供了一种中黑盲蝽insulin receptor substrate 1基因及其应用，属于昆虫基因工程技术领域。本发明所述基因的核苷酸序列如SEQ ID NO.1所示。本发明还设计了所述基因的RNA干扰序列，所述干扰序列dsRNA对中黑盲蝽insulin receptor substrate 1基因具有良好的沉默效果。注射该干扰序列，显著降低了中黑盲蝽卵巢的挂卵量，抑制了中黑盲蝽的产卵量，最终导致了中黑盲蝽的生殖能力下降，可以有效的控制其种群的发展，可用于转基因抗虫植物的开发以及中黑盲蝽的生物防治。

摘要： 本发明公开了一种Toll-like receptor-3(TLR3)激动剂在制备促进伤口愈合的药物中的应用。Toll-like receptor-3(TLR3)激动剂能够促进伤口的愈合，可作为促进伤口愈合的药物的活性成份，特别是polyriboinosinic polyribocytidylic acid，其能显著的缩短皮肤或者粘膜伤口的愈合时间，在临床治疗中，无搔痒、红肿热痛或其他不良反应，愈合后无明显瘢痕及皮肤质地改变，愈合质量高。本发明的polyriboinosinic polyribocytidylic acid有望作为正常个体、伤口难愈的个体或整形美容外科的伤口愈合的常规用药。