摘要:
背景:了解某一地区幽门螺杆菌(Hp)感染的流行病学现状,有利于制订针对性的疾病防治策略.目的:调查嘉兴市秀洲区体检和门诊人群的Hp感染状况,探讨Hp感染的影响因素.方法:收集2016年1月—2017年6月在浙江新安国际医院体检中心或门诊行Hp感染检测的当地成人,采集人口学资料以及生活和饮食习惯、药物史、胃镜诊疗史、口腔治疗史等信息.13C/ 14C-UBT、胃黏膜活检组织切片Giemsa染色、胃黏膜活检组织Hp培养三者中任一项阳性判定为Hp感染.结果:共4 220例受检者纳入研究,其中男性2 002例,女性2 218例,年龄18~80岁.Hp总体检出率为38. 1%,男性检出率显著高于女性(45. 0%对32. 0%,P<0. 05),中老年组(41~65岁)检出率显著高于青年组(18~40岁)和老年组(66~80岁)(45. 0%对31. 2%和32. 0%,P<0. 05).有烟酒嗜好和经常在外聚餐者Hp检出率显著增高(P<0. 05),长期服用非甾体消炎药(NSAIDs)者Hp检出率较低(P<0. 05),胃镜诊疗史和口腔治疗史与Hp检出率无明显关联(P>0. 05).结论:嘉兴市秀洲区体检和门诊人群的Hp检出率低于全国Hp现症感染率平均水平.不良生活习惯与Hp感染之间存在一定联系.%Background:Understanding the local epidemiologic features of Helicobacter pylori (Hp)infection might be helpful for formulating a targeted disease control strategy. Aims:To study the current status of Hp infection and its influencing factors in health examination subjects and outpatients in Xiuzhou District,Jiaxing,Zhejiang Province. Methods:Local residents who visited the health examination center or outpatient service for Hp test from Jan. 2016 to Jun. 2017 at Zhejiang Shin-an International Hospital were enrolled. Demographic data,life style,dietary habit,drug history and history of gastroscopy and dental treatment were collected to analyze the influencing factors of Hp infection. Positive for any of the three Hp tests:13 C/ 14C-UBT,biopsy pathology and bacterial culture was defined as Hp infection. Results:A total of 4 220 adults, including 2 002 males and 2 218 females with age ranged from 18 to 80 years were enrolled. The overall detection rate of Hp infection was 38. 1%. The detection rate in males was significantly higher than that in females (45. 0% vs. 32. 0%, P<0. 05). Also,the detection rate of middle-aged subjects (41-65 years)was significantly higher than those of young (18-40 years)and elderly subjects (66-80 years)(45. 0% vs. 31. 2% and 32. 0%,P <0. 05). Cigarette smoking, alcohol drinking,as well as dinner party were associated with higher detection rate of Hp infection (P<0. 05),while long-term use of non-steroidal anti-inflammatory drugs (NSAIDs)was associated with lower Hp detection rate (P<0. 05). No associations were found between gastroscopic procedure and dental treatment with the detection rate of Hp infection (P>0. 05). Conclusions:The detection rate of Hp infection in health examination subjects and outpatients in Xiuzhou District, Jiaxing,Zhejiang Province is relatively low when compared with the mean level in general population. Unhealthy life style is associated with the increased risk of Hp infection.